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BRCA Scan

BRCA Scan

Breast cancer is the most common malignancy among females in Saudi Arabia. The risk factors for developing this cancer type include age at menarche, obesity and diet. However, the biggest and most important risk factor is family history of breast cancer. The risk is particularly high if a first degree relative has been diagnosed with breast cancer. Mutations in the BRCA1 and BRCA2 genes often lead to the development of breast cancer and if these mutations are present in the germline then it can be passed on the following generations.

Who can benefit from BRCAScan?

BRCA1 and BRCA2 mutation testing should be considered for individuals with a personal or family history that suggests the presence of a harmful BRCA1/BRCA2 mutation. There are a variety of screening tools to help assess the risk of having a BRCA mutation. Some of the risk factors include: Breast cancer diagnosed at a young age, before age 50 years, Both breast and ovarian cancers in the same individual, or both breast and ovarian cancers in separate family members, Multiple breast cancers casin the family, A single family member with two or more primary types of BRCA-1 or BRCA-2related cancers, Breast cancer in a man or male relative, Breast cancer that is “triple negative” (estrogen receptor (ER), progesterone receptor (PR), and HER2 , negative). These factors should be considered for both the mother’s and father’s sides of the family. It is recommended that people be counseled by a genetics educator both before and after BRCA, mutation testing to receive sample awareness in order to understand the implications of a positive and/or negative result.

Who can benefit from BRCAScan?

BRCA1 and BRCA2 mutation testing should be considered for individuals with a personal or family history that suggests the presence of a harmful BRCA1/BRCA2 mutation. There are a variety of screening tools to help assess the risk of having a BRCA mutation. Some of the risk factors include: Breast cancer diagnosed at a young age, before age 50 years, Both breast and ovarian cancers in the same individual, or both breast and ovarian cancers in separate family members, Multiple breast cancers casin the family, A single family member with two or more primary types of BRCA-1 or BRCA-2related cancers, Breast cancer in a man or male relative, Breast cancer that is “triple negative” (estrogen receptor (ER), progesterone receptor (PR), and HER2 , negative). These factors should be considered for both the mother’s and father’s sides of the family. It is recommended that people be counseled by a genetics educator both before and after BRCA, mutation testing to receive sample awareness in order to understand the implications of a positive and/or negative result.

When should the test be ordered!

BRCA1 and BRCA2 mutation testing is not recommended as a screening tool for the general population. When someone has a personal or family history that suggests the presence of a harmful BRCA mutation, or carries one of the inclusive criteria mentioned above, that person may choose to undergo testing. The candidate should talk to their healthcare practitioner and seek counseling by a genetics educator/counselor prior to and after testing.

What does the test result mean?

The presence of a BRCA1 or BRCA2 mutation means that the person tested is at an increased risk for developing hereditary breast and/or ovarian cancer syndrome. It also indicates that the individual’s family members may be at an increased risk for breast or ovarian cancer. However, even within a family with the same BRCA mutation, not everyone will develop cancer and those who do may develop it at different times during their lives. According to the National Cancer Institute, estimates of lifetime risks for breast cancer in women are %55 to %65 for BRCA1 mutation and %45 for BRCA2 mutation. Risks of ovarian cancer is %39 with BRCA1 mutation and %11 to %19 with BRCA2 mutation.

Is there any other useful information you should know?

The degree of risk conferred with a positive result is difficult to quantify for a specific person. Results must be interpreted in conjunction with the tested person’s personal and family history. A genetic counselor explain thoroughly what the result means, treatment options for the individual that are intended to decrease risk, and testing options for other family members.
Genetic testing for BRCA1 and BRCA2 mutations cannot detect %100 causative mutations; thus, even with a negative result there is a small chance that there is a BRCA1 /BRCA2 gene mutation present. Additionally, there are other genes that may have mutations that can contribute to a family’s risk for cancer. Genetic testing for just BRCA1 or BRCA2 will only detect mutations in these two genes; therefore, if a mutation is present in another gene known to cause an increased risk for breast cancer, BRAC1/BRCA2 mutation testing will not detect it. In addition, sometimes a personal or family history of cancer may suggest a factor or combination of other factors that contribute to a person’s risk. In these families, it is likely that common risk factors that may include shared genes that sometimes cause cancer due to low penetrance, shared environment, exposures, and shared lifestyle increase the risk for cancer above that of the general population and sometimes increased cancer surveillance is recommended.
Positive test results may have implications for other family members. When one member of a family is tested for BRCAmutations,
issues often arise about how to share this information
with other family members.

To book an appointment for the BRCA Scan test

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